Discover the Hidden Link: How Lyme Disease Can Cause Knee Pain

lyme disease - Sriramakrishnahospital

Lyme disease, a tick borne disease caused by the bacterium Borrelia burgdorferi, is known for its diverse and often difficult symptoms. While most commonly associated with flu-like symptoms and the characteristic bullseye rash, Lyme disease can also manifest in unexpected ways. One such manifestation that often catches individuals by surprise is knee pain. Let’s explore the hidden link between Lyme disease and knee pain, shedding light on the mechanisms behind this connection and the importance of early detection and treatment. 

Understanding Lyme disease:

Before we understand the link between Lyme disease and knee pain, it’s crucial to understand the basics of this complex disease. Lyme disease is primarily transmitted through the bite of infected black-legged ticks, commonly known as deer ticks. The ticks are carriers of a specific bacteria that can infiltrate the bloodstream and spread throughout the body, leading to a range of symptoms. 

Although it’s important to remember that dog ticks and ordinary wood ticks do not carry Lyme disease. 

What are the common symptoms of Lyme disease?

Lyme disease can show the most common symptom of a bull’s eye rash at the site of the tick bite, this rash is also known as erythema migrans. The erythema migrans may not appear immediately but take about three to 30 days after the bite. There are various stages of Lyme disease that may be differentiated according to the stage. 

The Lyme disease symptoms can show both early stage and later stage symptoms. 

Early stage Lyme disease symptoms:

  • Fatigue 
  • Fever 
  • Chills 
  • Joint and muscle pains

These symptoms may resemble a flu-like condition as the bacteria begins to spread through the bloodstream. 

Later stage Lyme disease:

These symptoms may take several months to show after the tick bite. And the most common later stage Lyme disease symptoms like severe swelling and pain in the joints referred to a condition called “Lyme arthritis”. 

Additional Lyme disease in the later stage can cause neurological issues like:

  • Meningitis 
  • Shooting pain
  • Short term memory loss
  • Numbness in legs and hands

Usually, these neurological issues can take a few years to occur after the initial infection.

How long does Lyme disease skin rash last?

The rash typically develops in 1 to 4 weeks after being bitten by an infected tick, but it can take up to 3 months to show symptoms. It may continue for a few weeks. The center of the lyme disease rash may be lighter or darker, and it may spread over time. Usually, it’s not hot or scratchy.

What is the connection between Lyme disease and knee pain?

One of the lesser known facts about Lyme disease is that it can cause significant complications like Lyme arthritis, a condition characterized by joint inflammation, particularly affecting the knees. Lyme arthritis typically emerges weeks to months after the initial infection, and it can lead to persistent severe joint pain, swelling, and difficulty with mobility. 

The underlying mechanism behind Lyme arthritis is the body’s immune response to the persistent presence of the Borrelia burgdoferi bacterium. In some cases, the immune system, rather than effectively clearing the infection, mistakenly targets the joints, triggering an inflammatory response. 

This autoimmune reaction contributes to the development of arthritis and in particular, knee pain. Consult the best rheumatologist in Coimbatore if you are looking to get treatment for Lyme related knee issues.

What are the common symptoms of Lyme arthritis?

Individuals with Lyme arthritis may experience a wide range of symptoms, which often varies in its severity. Common signs include:


Lyme arthritis often results in the swelling of the affected knee joint. This can be visibly noticeable and may contribute to a feeling of stiffness. 


Joint pain is a hallmark of Lyme-related knee issues. The pain can be localized to the knee or may radiate to surrounding areas, making it difficult to distinguish from other causes of knee pain. 


Lyme arthritis can lead to joint stiffness, especially after periods of inactivity. This can affect the individual’s ability to move the knee freely. 

Redness and warmth:

Inflamed joints may exhibit redness and warmth due to increased blood flow to the affected area. These signs can be indicative of an active inflammatory response. 

What are the procedures involved in Lyme arthritis diagnosis?

Diagnosis of Lyme arthritis can be challenging, as the symptoms may overlap with other conditions such as osteoarthritis or even rheumatoid arthritis. Healthcare professionals typically consider a combination of clinical evaluation, patient history, and laboratory tests for an accurate diagnosis. 

Clinical examination:

A thorough physical examination is essential for assessing joint function, swelling, and signs that can be indicative of Lyme’s arthritis. A detailed patient history, including recent exposure to ticks or outdoor activities is important for diagnosis. 

Laboratory tests:

Blood tests, such as the enzyme-linked immunosorbent assay and Western blot, are commonly recommended to detect antibodies against the Lyme tick. However various other tests may be recommended to ensure a complete and accurate diagnosis. 

Imaging tests:

In some cases, imaging studies like X-rays or magnetic resonance imaging may be conducted to assess joint damage and rule out other potential causes of knee pain

What are the treatment and management options for Lyme arthritis? 

Early detection and prompt treatment are essential for managing Lyme-related knee pain effectively. The primary treatment for Lyme arthritis is antibiotics prescribed by a medical doctor. In addition to antibiotics, pain management strategies and anti-inflammatory medications may be prescribed to relieve symptoms and improve joint function. Physical therapy can also play a major role in restoring mobility and strength to the affected knee. 

What are the major tips to prevent Lyme disease and its complications?

Prevention remains the most effective strategy and also complications of Lyme disease. Here are some of the common tips to reduce the risk of Lyme disease,

Avoiding the tick bite:

Minimize the exposure to tick-infected areas, such as tall grass and wooded areas. Wear long sleeves, pants, and closed toes when going into such areas. 

Tick checks:

Perform thorough tick checks after spending time outdoors. Pay close attention to hidden areas like the groin, armpits, and scalp. Promptly remove any attached ticks with tweezers. 

Is Lyme disease serious?

Lyme disease can worsen if left untreated. Usually, three to ten weeks following a tick bite, the symptoms manifest. Stage 2 is frequently more extensive and grave. It is referred to as an early disseminated illness.

Important Takeaway:

Lyme disease is a complex and often misdiagnosed illness, capable of affecting various systems within the body. For individuals experiencing unexplained knee pain, especially in regions where Lyme disease is prevalent, it is crucial to consider the possibility of tick-borne infections. Early diagnosis and appropriate treatment not only alleviate symptoms but also prevent the progression of Lyme-related complications, including chronic joint issues. Reach out to the best hospital for rheumatology in Coimbatore if your knee pain seems to be unbearable. 

lyme disease - Sriramakrishnahospital

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